Antidiuretic Hormone Levels in Men with Burning Mouth Syndrome: A Pilot Study
이연희, 황미진, 전숙, 어규식,
소속 상세정보
이연희 ( Lee Yeon-Hee ) - Kyung Hee University Dental Hospital Department of Orofacial Pain and Oral Medicine
황미진 ( Hwang Mi-Jin ) - Kyung Hee University Dental Hospital Department of Orofacial Pain and Oral Medicine
전숙 ( Chon Suk ) - Kyung Hee University College of Medicine Department of Endocrinology and Metabolism
어규식 ( Auh Q-Schick ) - Kyung Hee University Dental Hospital Department of Orofacial Pain and Oral Medicine
Abstract
Purpose: Burning mouth syndrome (BMS) is a disabling pain that mostly occurs in elderly women, but rarely in men. It is characterized by an unremitting oral burning sensation and pain without detectable oral mucosal changes. We investigated the clinical and hematologic features of middle-aged men with BMS, and compared the results to those of men with oral mucositis.
Methods: Five men with BMS (48.60±6.19 years) and five age-matched controls with oral mucositis (49.80±15.26 years) underwent clinical and psychological evaluations and blood tests. Psychological status was evaluated using the Symptom Checklist-90-Revised. Cortisol, estradiol, progesterone, testosterone, follicle-stimulating hormone (FSH), luteinizing hormone (LH), adrenocorticotropic hormone (ACTH), and antidiuretic hormone (ADH) levels and erythrocyte sedimentation rate (ESR) were determined from the blood samples.
Results: ADH level was significantly lower in men with BMS than in the controls. ADH levels correlated with testosterone (p〈0.01), and ACTH levels strongly correlated with ESR (p〈0.05). Progesterone level positively correlated with FSH and LH levels. Pain intensity on a visual analogue scale correlated with estradiol level only in men with BMS. Among psychological factors, the obsessive-compulsive disorder, interpersonal-sensitivity, and anxiety scores were higher in men with BMS than in the controls (p〈0.05). However, no correlations were observed between the psychological and hematologic factors in both groups. The BMS symptoms presented only on the tongue, with the lateral border being the most prevalent area.
Conclusions: Men with BMS may experience dysregulated endocrinologic or psychoneuroendocrinologic interactions, which might affect oral BMS symptoms, aggravating the severity of the burning sensation.
키워드
Antidiuretic hormone; Blood; Burning mouth syndrome; Estradiol; Gonadal hormone; Male
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